2,2-Dimethyl-1,3-dioxane-4,6-dione → HCID 58857980, compound

Participants

Reaction Steps

Allyl(2Z)-3-(1-(2-(N′-(4-chlorophenyl)ureido)-3,3-dimethylbutyroyl)-4-piperidinyl)methyl-1,3-thiazol-2(3H)-ylidenecarbamate (0.33 g) obtained in Example 139c) and meldrum's acid (0.13 g) were dissolved in THF (10 ml). The solution was deaerated and substituted with argon. Tetrakis(triphenylphosphine)palladium (0.07 g) was added thereto, and mixed under argon atmosphere for 12 hours. The precipitated insolubles were filtered off, and the filtrate was concentrated under reduced pressure. The residue was purified with silica gel column to obtain the title compound as a pale yellow solid (0.14 g, 51%).

Provenance & Evidence