HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-benzyloxy-5-bromo-3-methyl-1H-quinolin-2-one → 8-Benzyloxy-3-methyl-5-vinyl-1H-quinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-benzyloxy-5-bromo-3-methyl-1H-quinolin-2-one | HCID 22499211 | — |
| Reactant | Tri(butyl)vinyltin | HCID 53438229 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 8-Benzyloxy-3-methyl-5-vinyl-1H-quinolin-2-one | HCID 22499178 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
Palladium terakis(triphenylphosphine) (30 mg) is added to a solution of 8-benzyloxy-5-bromo-3-methyl-1H-quinolin-2-one (239 mg) and tributylvinyltin (203 μL) in toluene (7 mL) at room temperature. The reaction mixture is heated for 2 hours at 100° C., cooled to room temperature, evaporated and the product purified by flash column chromatography on silica gel, eluting with 2% ethyl acetate in dichloromethane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820694B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-60f146b7f5ed4fb2801acb61ad4fe57f |
| Source note | uspto-grants-2010_10 |