HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3-Cyano-4-isobutoxyphenyl)boronic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Triisopropyl borate | HCID 21531 | — |
| Reactant | 5-Bromo-2-isobutoxybenzonitrile | HCID 66585134 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (3-Cyano-4-isobutoxyphenyl)boronic acid | HCID 54576546 | — |
Reaction Steps
5-Bromo-2-isobutoxybenzonitrile and triisopropylborate were dissolved in a mixed solvent of THF and toluene and an n-butyllithium-hexane solution was added dropwise to the solution at a temperature below −60° C. After the temperature was elevated to −20° C., 1M hydrochloric acid was added, followed by stirring at room temperature to obtain (3-cyano-4-isobutoxyphenyl)boronic acid. F: 220.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820700B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-5c2072699cf044508f6608dd22a54d8f |
| Source note | uspto-grants-2010_10 |