HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → Methyl 2-chloro-3-fluoropyridine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | Methyl 3-fluoropyridine-4-carboxylate | HCID 46311148 | — |
| Product | Methyl 2-chloro-3-fluoropyridine-4-carboxylate | HCID 24820381 | — |
| Product | Methyl 2-chloro-5-fluoroisonicotinate fluoroisonicotinate | HCID 131728397 | — |
Reaction Steps
Methyl 3-fluoroisonicotinate was oxidized with 3-chloroperbenzoic acid, followed by heating in the presence of phosphoryl chloride. The product was separated by silica gel column chromatography to obtain methyl 2-chloro-5-fluoroisonicotinate fluoroisonicotinate (EI: 189) and methyl 2-chloro-3-fluoroisonicotinate (EI: 189).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820700B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-149357de13324d49bb726a683f0bf132 |
| Source note | uspto-grants-2010_10 |