(Bromomethyl)cyclobutane → HCID 68647487, compound

HRID 1162422Notes

Reaction equation

HRID 1162422 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:10]2[CH:11]=[C:12]([CH:17]=[CH:18][N:19]=2)[C:13]([O:15]C)=[O:14])[CH:6]=[CH:7][C:8]=1[OH:9])#[N:2].[CH:20]1([CH2:24]Br)[CH2:23][CH2:22][CH2:21]1>>[C:1]([C:3]1[CH:4]=[C:5]([C:10]2[CH:11]=[C:12]([CH:17]=[CH:18][N:19]=2)[C:13]([OH:15])=[O:14])[CH:6]=[CH:7][C:8]=1[O:9][CH2:24][CH:20]1[CH2:23][CH2:22][CH2:21]1)#[N:2]

Participants

3

Reactant 2

HCID 2734658(Bromomethyl)cyclobutaneHCID 136368377Methyl 2-(3-cyano-4-hydroxyphenyl)isonicotinate

Product 1

HCID 68647487HCID 68647487, compound

Procedure

Using methyl 2-(3-cyano-4-hydroxyphenyl)isonicotinate and cyclobutylmethyl bromide, 2-[3-cyano-4-(cyclobutylmethoxy)phenyl]isonicotinic acid was obtained according to the method of Example 2. Then, 150 mg of the compound was suspended in 5 ml of methanol, and 32 mg of sodium methoxide was added to the suspension at 0° C., followed by stirring for 3 hours with gradual elevation of the temperature to room temperature. The reaction solution was concentrated under reduced pressure to obtain 115 mg of sodium 2-[3-cyano-4-(cyclobutylmethoxy)phenyl]isonicotinate.

Sources & evidence

ORD record
ord-55d3675b0da94dbe92011f876d0e44f4
Source dataset
uspto-grants-2010_10
Patent number
US07820700B2

Reaction notes

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