2-Fluoropyridine-4-boronic acid → N-(6-(2-Fluoropyridin-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide

Participants

Reaction Steps

Following the procedure described for N-(6-(3-(4-methylphenylsulfonamido)phenyl)imidazo[1,2-b]pyridazin-2-yl)acetamide (Example 1), N-(6-chloroimidazo[1,2-b]pyridazin-2-yl)acetamide (Example 1, Step 4) (0.040 g, 0.19 mmol) was reacted with 2-fluoropyridin-4-ylboronic acid (0.054 g, 0.38 mmol, Synthonix, Wake Forest, N.C.) to afford the title compound as a yellow solid. MS (ESI positive ion) m/z: 272 (M+1). 1H NMR (400 MHz, DMSO-d6): δ pp, 11.00 (s, 1H), 8.43 (d, J=5.3 Hz, 1H), 8.18 (d, J=10.0 Hz, 1H), 8.05 (t, J=1.6 Hz, 0.5H), 8.04 (t, J=1.6 Hz, 0.5H), 7.96 (d, J=9.4 Hz, 1H), 7.86 (s, 1H), 2.13 (s, 3H).

Provenance & Evidence