3-Aminophenylboronic acid → N-(6-(3-Aminophenyl)imidazo[1,2-b]pyridazin-2-yl)acetamide

Participants

Reaction Steps

Following the procedure described for compound N-(6-(3-(4-methylphenylsulfonamido)phenyl)imidazo[1,2-b]pyridazin-2-yl)acetamide (Example 1), N-(6-chloroimidazo[1,2-b]pyridazin-2-yl)acetamide (Example 1, Step 4) (0.071 g, 0.34 mmol) was reacted with 3-aminobenzeneboronic acid (0.094 g, 0.60 mmol, Alfa Aesar, Avocado Organics, Ward Hill, Mass.) to afford the title compound as a yellow solid. MS (ESI positive ion) m/z: 268 (M+1). 1H NMR (400 MHz, DMSO-d6): δ ppm 10.87 (s, 1H), 8.24 (s, 1H), 8.00 (d, J=9.4 Hz, 1H), 7.62 (d, J=9.4 Hz, 1H), 7.25 (t, J=1.9 Hz, 1H), 7.12-7.19 (m, 2H), 6.69-6.71 (m, 1H), 5.30 (s, 2H), 2.11 (s, 3H).

Provenance & Evidence