反应详情

Following the procedure described for N-(6-(3-(4-methylphenylsulfonamido)phenyl)imidazo[1,2-b]pyridazin-2-yl)acetamide (Example 1), N-(6-chloroimidazo[1,2-b]pyridazin-2-yl)acetamide (Example 1, Step 4) (0.075 g, 0.36 mmol) was reacted with 5-(methylthio)pyridin-3-ylboronic acid (0.11 g, 0.64 mmol, Combi-Blocks, San Diego, Calif.) to afford the title compound as a white solid. MS (ESI positive ion) m/z: 300 (M+1). 1H NMR (400 MHz, DMSO-d6): δ ppm 10.94 (s, 1H), 9.00 (d, J=2.0 Hz, 1H), 8.60 (d, J=2.2 Hz, 1H), 8.34 (s, 1H), 8.27 (t, J=2.2 Hz, 1H), 8.12 (d, J=9.4 Hz, 1H), 7.90 (d, J=9.4 Hz, 1H), 2.64 (s, 3H), 2.12 (s, 3H).