3-(Methylthio)benzeneboronic acid → N-(6-(3-(Methylthio)phenyl)imidazo[1,2-b]pyridazin-2-yl)acetamide

Participants

Reaction Steps

Following the procedure described for compound N-(6-(3-(4-methylphenylsulfonamido)phenyl)imidazo[1,2-b]pyridazin-2-yl)acetamide (Example 1), N-(6-chloroimidazo[1,2-b]pyridazin-2-yl)acetamide (Example 1, Step 4) (0.075 g, 0.36 mmol) was reacted with 3-(methylthio)phenylboronic acid (0.11 g, 0.64 mmol, Alfa Aesar, Ward Hill, Mass.) to afford the title compound as a yellow solid. MS (ESI positive ion) m/z: 299 (M+1). 1H NMR (400 MHz, DMSO-d6): δ ppm 10.91 (s, 1H), 8.30 (s, 1H), 8.06 (d, J=9.6 Hz, 1H), 7.90 (s, 1H), 7.80-7.82 (m, 2H), 7.49 (t, J=7.8 Hz, 1H), 7.40-7.42 (m, 1H), 2.57 (s, 3H), 2.11 (s, 3H).

Provenance & Evidence