5-(Methylsulphonyl)pyridine-3-boronic acid → HCID 44124752, compound

Participants

Reaction Steps

Following the procedure described for compound N-(6-(3-(4-methylphenylsulfonamido)phenyl)imidazo[1,2-b]pyridazin-2-yl)acetamide (Example 1), N-(6-chloroimidazo[1,2-b]pyridazin-2-yl)acetamide (Example 1, Step 4) (0.084 g, 0.40 mmol) was reacted with 5-(methylsulfonyl)pyridin-3-ylboronic acid (0.14 g, 0.72 mmol, Combi-Blocks, San Diego, Calif.) to afford the title compound as a yellow solid. MS (ESI positive ion) m/z: 332 (M+1). 1H NMR (400 MHz, DMSO-d6): δ ppm 10.97 (s, 1H), 9.56 (d, J=2.2 Hz, 1H), 9.19 (d, J=2.2 Hz, 1H), 8.89 (t, J=2.2 Hz, 1H), 8.39 (s, 1H), 8.19 (d, J=9.4 Hz, 1H), 8.00 (d, J=9.4 Hz, 1H), 3.31 (s, 3H), 2.12 (s, 3H).

Provenance & Evidence