Sodium Hydroxide → N-(5-(2-Amino-3-(pyridin-4-yl)imidazo[1,2-b]pyridazin-6-yl)-2-chloropyridin-3-yl)methanesulfonamide

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Reaction Steps

Following the procedure described for N-(5-(2-amino-3-(3-fluorophenyl)imidazo[1,2-b]pyridazin-6-yl)-2-chloropyridin-3-yl)methanesulfonamide (Example 23), N-(6-(6-chloro-5-(methylsulfonamido)pyridin-3-yl)-3-(pyridin-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide (TFA salt) (Example 26) (0.040 g, 0.070 mmol) was reacted with sodium hydroxide (0.200 mL, 2.0 mmol, 10 M) at 50° C. for 28 h to afford the title compound as a yellow solid (0.0210 g, 72%). MS (ESI, positive ion) m/z: 416 (M+1). 1H NMR (400 MHz, DMSO-d6) δ ppm 3.20 (s, 3H), 6.26 (s, 2H), 7.88 (d, J=9.2 Hz, 1H), 7.95 (d, J=9.2 Hz, 1H), 8.08 (d, J=6.1 Hz, 2H), 8.57 (d, J=2.2 Hz, 1H), 8.63 (d, J=6.1 Hz, 2H), 8.89 (br s, 1H), 9.94 (br s, 1H).

Provenance & Evidence