1-Phenethylamine → 1-Phenethylamine, (+)-

HRID 1162536Notes

Reaction equation

HRID 1162536 reaction equation
C([C@H](CCCCCC)C(O)=O)CC.[C:14]1([CH:20]([NH2:22])[CH3:21])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(#N)C>[C:14]1([C@H:20]([NH2:22])[CH3:21])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 74081-PhenethylamineHCID 208925(R)-(-)-2-propyloctanoic acid2×

Product 1

HCID 6431891-Phenethylamine, (+)-Yield 88.2%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Using the crystal comprising (2R)-2-propyloctanoic acid and R)-(+)-1-phenylethylamine (6.8 g) produced in the second recrystallization and acetonitrile (102 mL), the same operation as in the second recrystallization was made to give the crystal comprising (2R)-2-propyloctanoic acid and (R)-(+)-1-phenylethylamine (6.0 g, 98.9% e.e.; yield 88%).

Workup

  1. customthe same operation as in the second recrystallization
  2. customto give the crystal

Sources & evidence

ORD record
ord-54191d2ebb5b469a828f5070eff5df6b
Source dataset
uspto-grants-2010_10
Patent number
US07820715B2

Reaction notes

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