Sodium hydride → HCID 59520368, compound

Participants

Reaction Steps

N-[4-(4-Isopropyl-phenyl)-thiazol-2-yl]-2,5-dimethoxy-benzenesulfonamide was prepared (62 mg) following general procedure C (method 1) using 4-(4-isopropyl-phenyl)-thiazol-2-yl amine (50 mg, 0.23 mmol), 2,5-dimethoxybenzenesulfonyl chloride (59 mg, 0.25 mmol), NaH (14 mg, 60%, 0.34 mmol) and THF (1 mL). LCMS m/z: 419 (M+1)+; 1H NMR (CDCl3, 400 MHz): δ 1.27 (d, 6H); 2.95 (m, 1H), 3.75 (s, 3H), 3.81 (3, 3H), 6.52 (s, 1H), 6.9 (d, 1H), 7.0 (dd, 1H), 7.31 (m, 2H), 7.44 (m, 2H), 7.6 (d, 1H), 10.2 (brs, 1H).

Provenance & Evidence