Hydrochloric Acid → [4-(4-Isopropyl-phenyl)-thiazol-2-ylsulfamoyl]-acetic acid

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	HCID 59520223	HCID 59520223	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	[4-(4-Isopropyl-phenyl)-thiazol-2-ylsulfamoyl]-acetic acid	HCID 59520176	—

Reaction Steps

[4-(4-Isopropyl-phenyl)-thiazol-2-ylsulfamoyl]-acetic acid tert-butyl ester was combined with 4M HCl in dioxane as in general procedure G1 to furnish [4-(4-Isopropyl-phenyl)-thiazol-2-ylsulfamoyl]-acetic acid. LCMS m/z: 342 (M+1)+; 1H NMR (DMSO-d6, 400 MHz): δ 1.22 (d, 6H); 2.92 (m, 1H); 4.04 (s, 2H); 7.17 (s, 1H); 7.33 (d, 2H); 7.66 (d, 2H); 12.98 (s); 13.2 (s).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07820704B2
Source dataset	uspto-grants-2010_10
ORD ID	ord-7a2e1a842afa4d388209f613fe55071e
Source note	uspto-grants-2010_10