HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Thiophenecarboxaldehyde → HCID 86601760, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Thiophenecarboxaldehyde | HCID 7364 | — |
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | Fmoc isothiocyanate | HCID 4154759 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | Tert-butyl 3-aminopropanoate hydrochloride | HCID 16218890 | — |
| Product | HCID 86601760 | HCID 86601760 | — |
Reaction Steps
3-(1-Thiophen-2-ylmethyl-thioureido)-propionic acid tert-butyl ester was prepared (750 mg) following general procedure D using thiophene-2-carbaldehyde (0.466 mL, 5 mmol), beta-alanine tert-butyl ester hydrochloride (905 mg, 5 mmol), sodium triacetoxyborohydride (1.27 g, 6 mmol), Fmoc isothiocyanate (1.4 g, 95.3%, 5 mmol), and diethyl amine (2 mL). LCMS m/z: 301 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820704B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-5def32bf0c67453a8756b3594da9a097 |
| Source note | uspto-grants-2010_10 |