HCID 43188688, compound → HCID 178461402, compound

HRID 1162559Notes

Reaction equation

HRID 1162559 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][CH:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15](=[O:17])[CH3:16])=[CH:11][CH:10]=2)[CH2:4][CH2:3]1.C1CNC(=O)C1.[Br:24][Br-]Br>>[Br:24][CH2:16][C:15]([C:12]1[CH:13]=[CH:14][C:9]([O:8][C@H:5]2[CH2:4][CH2:3][C@@H:2]([CH3:1])[CH2:7][CH2:6]2)=[CH:10][CH:11]=1)=[O:17]

Participants

2

Reactant 1

HCID 43188688HCID 43188688, compound

Product 1

HCID 178461402HCID 178461402, compoundYield 104.4%

Procedure

2-Bromo-1-[4-(cis-4-methyl-cyclohexyloxy)-phenyl]-ethanone (650 mg) was prepared following procedure A using 1-[4-(4-Methyl-cyclohexyloxy)-phenyl]-ethanone (464 mg, 2.0 mmol) and pyrrolidone hydrotribromide (701 mg, 2.2 mmol).

Sources & evidence

ORD record
ord-8dfab1019ef74572b7332de7fcc20653
Source dataset
uspto-grants-2010_10
Patent number
US07820704B2

Reaction notes

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