HCID 86079888, compound → HCID 178461401, compound

Participants

Reaction Steps

4-[(Cyclopentyl-{4-[4-(cis-4-methyl-cyclohexyloxy)-phenyl]-thiazol-2-yl}-amino)-methyl]-benzoic acid (90 mg) was prepared following procedure B using 4-[(1-cyclopentyl-thioureido)-methyl]-benzoic acid methyl ester (150 mg, 0.5 mmol) and 2-bromo-1-[4-(4-methyl-cyclohexyloxy)-phenyl]-ethanone (0.5 mmol). Purification (Silica gel, ethyl acetate/hexane 5:95) provided the ester, which was hydrolyzed following procedure T. Sodium 4-[(cyclopentyl-{4-[4-(cis-4-methyl-cyclohexyloxy)-phenyl]-thiazol-2-yl}-amino)-methyl]-benzoate was made following procedure J. LCMS m/z: 492 (M+1)+.

Provenance & Evidence