4-Isopropylphenylboronic acid → HCID 178438902, compound

HRID 1162564Notes

Reaction equation

HRID 1162564 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1.[CH:15]([C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1)([CH3:17])[CH3:16]>>[CH:15]([C:18]1[CH:23]=[CH:22][C:21]([C:6]2([NH:8][CH2:9][C:10]3[S:11][CH:12]=[CH:13][CH:14]=3)[CH:5]=[CH:4][N:3]=[CH:2][NH:7]2)=[CH:20][CH:19]=1)([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 27734804-Isopropylphenylboronic acidHCID 22308399HCID 22308399, compound

Product 1

HCID 178438902HCID 178438902, compound

Procedure

[2-(4-Isopropyl-phenyl)-pyrimidin-4-yl]-thiophen-2-ylmethyl-amine (142 mg) was obtained by following general procedure Q1 from (2-chloro-pyrimidin-4-yl)-thiophen-2-ylmethyl-amine (130 mg, 0.58 mmol) and 4-isopropylphenylboronic acid (140 mg, 0.86 mmol). LCMS m/z: 311 (M+1)+. [4-(4-Isopropyl-phenyl)-pyrimidin-4-yl]-thiophen-2-ylmethyl-amine was obtained by following general procedure Q1 from (4-Chloro-pyrimidin-2-yl)-thiophen-2-ylmethyl-amine and 4-isopropylphenylboronic acid.

Sources & evidence

ORD record
ord-57ab2e1693fd400186def4c2b7110fab
Source dataset
uspto-grants-2010_10
Patent number
US07820704B2

Reaction notes

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