tert-Butyl bromoacetate → HCID 68647494, compound

HRID 1162566Notes

Reaction equation

HRID 1162566 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:17]=[CH:16][N:15]=[C:14]([C:18]3[CH:23]=[CH:22][C:21]([CH:24]([CH3:26])[CH3:25])=[CH:20][CH:19]=3)[N:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[C:27]([O:31][C:32](=[O:35])[CH2:33]Br)([CH3:30])([CH3:29])[CH3:28]>>[C:27]([O:31][C:32](=[O:35])[CH2:33][N:11]([S:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)(=[O:10])=[O:9])[C:12]1[CH:17]=[CH:16][N:15]=[C:14]([C:18]2[CH:23]=[CH:22][C:21]([CH:24]([CH3:26])[CH3:25])=[CH:20][CH:19]=2)[N:13]=1)([CH3:30])([CH3:29])[CH3:28]

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 59520278HCID 59520278, compound

Product 1

HCID 68647494HCID 68647494, compound

Procedure

{(4-Chloro-benzenesulfonyl)-[2-(4-isopropyl-phenyl)-pyrimidin-4-yl]-amino}-acetic acid tert-butyl ester was prepared (97 mg) from 4-chloro-N-[2-(4-isopropyl-phenyl)-pyrimidin-4-yl]-benzenesulfonamide (100 mg, 0.26 mmol) (Prepared in Example 158) and bromoacetic acid tert-butyl ester by following the general procedure S (method 1). LCMS m/z: 503 (M+1)+.

Sources & evidence

ORD record
ord-72b68d0b531b48cdb9b5a9b627f26661
Source dataset
uspto-grants-2010_10
Patent number
US07820704B2

Reaction notes

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