Bromoacetonitrile → HCID 178438893, compound

HRID 1162567Notes

Reaction equation

HRID 1162567 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[N:17]=[C:16]([C:18]3[CH:23]=[CH:22][C:21]([CH:24]([CH3:26])[CH3:25])=[CH:20][CH:19]=3)[CH:15]=[CH:14][N:13]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.Br[CH2:28][C:29]#[N:30].[NH:31]1C=N[N:33]=[N:32]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([N:11]([C:12]2[N:17]=[C:16]([C:18]3[CH:23]=[CH:22][C:21]([CH:24]([CH3:26])[CH3:25])=[CH:20][CH:19]=3)[CH:15]=[CH:14][N:13]=2)[CH2:28][C:29]2[NH:30][N:33]=[N:32][N:31]=2)(=[O:10])=[O:9])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 11534BromoacetonitrileHCID 59520190HCID 59520190, compoundHCID 178418441HCID 178418441, compound

Product 1

HCID 178438893HCID 178438893, compound

Procedure

4-Chloro-N-[4-(4-isopropyl-phenyl)-pyrimidin-2-yl]-N-(1H-tetrazol-5-yl methyl)-benzenesulfonamide was prepared from 4-chloro-N-[4-(4-isopropyl-phenyl)-pyrimidin-2yl]-benzenesulfonamide via N-alkylation with bromoacetonitrile using general procedure S (method 1) followed by tetrazole formation using general procedure H. LCMS m/z: 471 (M+1)+.

Sources & evidence

ORD record
ord-3e63fe3c34ee42b789851563b9408bcb
Source dataset
uspto-grants-2010_10
Patent number
US07820704B2

Reaction notes

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