HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopentylamine → Cyclopentylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopentylamine | HCID 2906 | — |
| Reactant | 2,4-Dichloropyrimidine | HCID 77531 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Cyclopentylamine | HCID 2906 | 209.6% |
| Product | 4-Pyrimidinamine, 2-chloro-N-cyclopentyl- | HCID 62344053 | — |
| Product | HCID 86079789 | HCID 86079789 | — |
Reaction Steps
(2-Chloro-pyrimidin-4yl)-cyclopentyl-amine and (4-chloro-pyrimidin-2yl)-cyclopentyl-amine were synthesized from 2,4 dichloropyrimidine (1.0 g, 6.7 mmol), cyclopentylamine (860 mg, 10.1 mmol) and DIEA (3.5 mL, 20.2 mmol) following procedure P, method P2, using THF as solvent. The crude products were purified by silica gel chromatography eluting with DCM/ethyl acetate (9:1) to afford 2-Chloro-pyrimidin-4-yl)-cyclopentyl-amine (598 mg). LCMS m/z: 199 (M+1)+, and (4-chloro-pyrimidin-2-yl)-cyclopentyl-amine (285 mg). LCMS m/z: 199 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820704B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-50b65b86bf3546b78f863688a173a652 |
| Source note | uspto-grants-2010_10 |