HCID 68647974, compound → HCID 136352438, compound

Participants

Reaction Steps

To a MeOH-DCM solution (4:1, 4 mL) of 3-({[2-(4-benzyloxy-phenyl)-pyrimidin-4-yl]-cyclopentyl-amino}-methyl)-benzoic acid methyl ester (116 mg, 0.235 mmol) was added 10% Pd/C (25 mg), and the reaction mixture was stirred at room temperature for 2 h under a hydrogen atmosphere (balloon). The mixture was filtered through a pad of Celite and then concentrated. The 3-({cyclopentyl-[2-(4-hydroxy-phenyl)-pyrimidin-4-yl]-amino}-methyl)-benzoic acid methyl ester obtained was used without further purification. LCMS m/z: 405 (M+1)+.

Provenance & Evidence