Methanesulfonamide → HCID 59520214, compound

Participants

Reaction Steps

A mixture of 3-{[4-(4-Isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-amino}-propionic acid (50 mg, 0.14 mmol), diphenyl phosphoryl azide (50 uL, 0.18 mmol) and DIEA (100 μL) was heated in CH3CN at 60° C. for 1 hour. After cooling to room temperature methane sulfonamide (30 mg, 0.32 mmol) was added and reaction mixture was stirred. After 16 h, the reaction mixture was concentrated in high vacuum. The crude residue was purified on silica gel column (ethyl acetate/hexane 1:1) to afford (2-{[4-(4-Isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-amino}-ethyl) 3-methanesulfonyl-urea (15 mg). LCMS m/z: 480 (M+1)+.

Provenance & Evidence