2-Bromo-1-(4-(propan-2-yl)phenyl)ethan-1-one → 4-{Cyclopentyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amino}-butyric acid

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Reaction Steps

4-{Cyclopentyl-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-amino}-butyric acid was prepared according to general procedure B using 4-(1-cyclopentyl-thioureido)-butyric acid methyl ester (70 mg, 0.3 mmol) and 2-bromo-4′-isopropylacetophenone (80.0 mg, 0.3 mmol). Purification (Silica gel, ethyl acetate/hexane 5:95) provided the ester, which was hydrolyzed following general procedure T. LCMS m/z: 374 (M+1)+.

Provenance & Evidence