Hydrochloric Acid → HCID 68648072, compound

Participants

Reaction Steps

To the 3-[[4-(4-isopropyl-phenyl)-thiazol-2-yl]-(2-thiophen-2-yl-ethyl)-amino]-propionic acid ethyl ester (95 mg, 0.22 mmol) was added LiOH (3 mL; 2N LiOH-MeOH-THF=1:1:4) and the reaction was stirred at room temperature for 4 h before acidifying with 1 N HCl. Brine was added, and the mixture was extracted with DCM (3×10 ml). The combined extracts were dried over Na2SO4, concentrated and purified on silica gel column to provide 3-[[4-(4-isopropyl-phenyl)-thiazol-2-yl]-(2-thiophen-2-yl-ethyl)-amino]-propionic acid hydrochloride salt (58 mg). LCMS m/z: 402 (M+1)+.

Provenance & Evidence