HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 24657609, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Cyclobutanecarbonyl chloride | HCID 78705 | — |
| Reactant | 4-(4-Isopropyl-phenyl)-thiazol-2-ylamine | HCID 673693 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 24657609 | HCID 24657609 | 80% |
Reaction Steps
4-(4-Isopropyl-phenyl)-thiazol-2-yl amine (90 mg, 0.41 mmol) was acylated in CH2Cl2 using cyclobutane carbonyl chloride (60 μL, 0.52 mmol, 1.25 eq.) in the presence of excess pyridine. The reaction was quenched with sat. NH4Cl, extracted with EtOAc and dried over MgSO4. Purification by silica gel chromatography (10% EtOAc in hexanes) afforded 95 mg (80%) of cyclobutanecarboxylic acid [4-(4-isopropyl-phenyl)-thiazol-2-yl]-amide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820704B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-620e103ccd1c42cda0b324d78670dd83 |
| Source note | uspto-grants-2010_10 |