Hydrochloric Acid → methyl 1H-indazole-3-carboxylate

Participants

Reaction Steps

To the methanol solution of 1H-indazole-3-carboxylic acid (162 mg, 1 mmol) was added 4N HCl in dioxane (2 mL) and the mixture was stirred at the room temperature for 24 h. After evaporation of the volatiles, the mixture was partitioned between aqueous NaHCO3 solution and ethyl acetate. The aqueous phase was extracted with ethyl acetate (2×15 mL), and the combined organic layer was dried over sodium sulfate. The volatiles were removed, and the residue was filtered over silica gel to provide 1H-Indazole-3-carboxylic acid methyl ester (123 mg). LCMS m/z: 177 (M+1)+.

Provenance & Evidence