Hydrochloric Acid → HCID 68648325, compound

Participants

Reaction Steps

To the 1-[4-(4-isopropyl-phenyl)-thiazol-2-yl]-1H-indazole-3-carboxylic acid methyl ester (150 mg, 0.22 mmol) was added LiOH (5 mL; 2N LiOH-MeOH-THF=1:1:4) and stirred at room temperature for 4 h before acidifying with 1N HCl. Brine was added and the aqueous was extracted with DCM (3×15 ml). Combined extracts were dried over Na2SO4, concentrated and purified on silica gel column to provide 1-[4-(4-Isopropyl-phenyl)-thiazol-2-yl]-1H-indazole-3-carboxylic acid hydrochloride salt (48 mg). LCMS m/z: 365 (M+1)+.

Provenance & Evidence