HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Thiophenecarboxaldehyde → HCID 86601764, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Thiophenecarboxaldehyde | HCID 7364 | — |
| Reactant | Benzoic acid, 3-amino-, methyl ester | HCID 78274 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | HCID 43087835 | HCID 43087835 | — |
| Product | HCID 86601764 | HCID 86601764 | 89.6% |
Reaction Steps
3-Amino-benzoic acid methyl ester (455 mg, 3.0 mmol), thiophene carboxaldehyde (290 μL, 3.15 mmol) and sodium triacetoxyborohydride (765 mg, 3.6 mmol) were combined according to general procedure D. 189 mg of the crude 3-[(thiophen-2-ylmethyl)-amino]-benzoic acid methyl ester (0.75 mmol) was treated with 1 eq. Fmoc-NCS to afford 206 mg 3-(1-thiophen-2-ylmethyl-thioureido)-benzoic acid methyl ester after purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820704B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-b9f59cba294244fbbe4c88926ae3df59 |
| Source note | uspto-grants-2010_10 |