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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1162603Generated: November 4, 2026

Ethyl nipecotate → Ethyl 1-carbamothioylpiperidine-3-carboxylate

https://huagongshe.com/reaction/1162603

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl nipecotateHCID 98969—
ReactantFmoc isothiocyanateHCID 4154759—
ProductEthyl 1-carbamothioylpiperidine-3-carboxylateHCID 4511865192.5%

Reaction Steps

1-Thiocarbamoyl-piperdine-3-carboxylic acid ethyl ester (400 mg) was prepared following general procedure D using piperdine-3-carboxylic acid ethyl ester (315 mg, 2.0 mmol), and Fmoc-isothiocyanate (562 mg, 2.0 mmol). Purification: (Silica gel, ethyl acetate/hexane 1:1). LCMS m/z 217.0 (M+1)+

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07820704B2
Source datasetuspto-grants-2010_10
ORD IDord-df65ef87250d4afbb91b76b4a7faabdc
Source noteuspto-grants-2010_10