Ethyl bromoacetate → HCID 58748156, compound

HRID 1162606Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][C@@H:9]1[CH2:13][CH2:12][NH:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:14]([O:16][C:17](=[O:20])[CH2:18]Br)[CH3:15]>>[CH2:14]([O:16][C:17](=[O:20])[CH2:18][N:11]1[CH2:12][CH2:13][C@@H:9]([NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])=[O:7])[CH2:10]1)[CH3:15]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 1514397(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine

Product 1

HCID 58748156HCID 58748156, compound

Procedure

1.1 Using general procedure A, (R)-(+)-3-(tert-butyloxycarbonylamino)-pyrrolidine was alkylated with bromoacetic acid ethyl ester to give ((R)-3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-acetic acid ethyl ester. Off-white solid. MS 273.1 ([M+H]+)

Sources & evidence

ORD record: ord-01cb72e3797c4a618c21ba0f9f0c5212
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07820699B2

Reaction notes

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