1-(4-Amino-3-fluorophenyl)pyridin-2-one → HCID 42628060, compound

Participants

Reaction Steps

1.4 Using general method F, {(R)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-pyrrolidin-1-yl}-acetic acid ethyl ester was reacted with 1-(4-amino-3-fluoro-phenyl)-1H-pyridin-2-one (CAS 536747-52-1, prepared according to WO 2003045912) to give 5-chloro-thiophene-2-carboxylic acid ((R)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-pyrrolidin-3-yl)-amide. Off-white amorphous solid. Light yellow solid. MS 475.3 ([M+H]+)

Provenance & Evidence