HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-bromopropionate → 2-{(R)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-pyrrolidin-1-yl}-propionic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-bromopropionate | HCID 79040 | — |
| Reactant | 5-chloro-thiophene-2-carboxylic acid (R)-pyrrolidin-3-ylamide hydrochloride | HCID 86608828 | — |
| Product | 2-{(R)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-pyrrolidin-1-yl}-propionic acid ethyl ester | HCID 58748289 | — |
Reaction Steps
6.3 Using general procedure A 5-chloro-thiophene-2-carboxylic acid (R)-pyrrolidin-3-ylamide hydrochloride was reacted with ethyl-2-bromopropionate to give 2-{(R)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-pyrrolidin-1-yl}-propionic acid ethyl ester. Oil. MS 329.1 ([M−H]−)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820699B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-dd846a59875f48cc920f940df4b4bd86 |
| Source note | uspto-grants-2010_10 |