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HRID1162612

反应详情

EQUATION

反应方程式

HRID 1162612 的结构方程式

REACTANTS

反应物

2
结构：Nc1ccc(-n2ccccc2=O)cc1F
HCID22181548

1-(4-Amino-3-fluorophenyl)pyridin-2(1H)-one

C11H9FN2O

结构：CCOC(=O)C(C)N1CC[C@@H](NC(=O)c2ccc(Cl)s2)C1
HCID58748289

未命名化合物

PRODUCTS

生成物

1
结构：CC(C(=O)Nc1ccc(-n2ccccc2=O)cc1F)N1CC[C@@H](NC(=O)c2ccc(Cl)s2)C1
HCID58748343

未命名化合物

PROCEDURE

实验过程

6.4 Using general procedure F 2-{(R)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-pyrrolidin-1-yl}-propionic acid ethyl ester was reacted with 1-(4-amino-3-fluoro-phenyl)-1H-pyridin-2-one (CAS 536747-52-1, prepared according to WO 2003045912) to give 5-chloro-thiophene-2-carboxylic acid ((R)-1-{1-[2-fluoro-4-(2-oxo-pyridin-1-yl)-phenylcarbamoyl]-ethyl}-pyrrolidin-3-yl)-amide. Yellow solid. MS 487.4 ([M−H]−)