Hydrochloric Acid → HCID 58748275, compound

Participants

Reaction Steps

9.2 To a stirred solution of {3-[(5-chloro-thiophene-2-carbonyl)-amino]-piperidin-1-yl}-acetic acid ethyl ester at r.t. in 5 ml ethanol were added 5 ml 1 N NaOH. The slurry slowly turned to a clear solution. Stirring at r.t. was then continued for 5 h. The mixture was neutralized by adding 5 ml of 1 N HCl (pH ˜7). The light orange solution was concentrated to leave an off-white solid. This residue was coevaporated several times with toluene to remove the remaining H2O, and dried overnight (r.t., 0.5 mbar) to give 1.07 g {3-[(5-chloro-thiophene-2-carbonyl)-amino]-piperidin-1-yl}-acetic acid (containing 2 mol equivalents of sodium chloride). Off-white solid. MS 301.3 ([M−H]−)

Provenance & Evidence