5-Chloro-2-thiophenecarboxylic acid → (2S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Participants

Role	Name	HCID	Charge
Reactant	5-Chloro-2-thiophenecarboxylic acid	HCID 95048	—
Reactant	Methyl (2S,4R)-4-aminopyrrolidine-2-carboxylate hydrochloride, N1-BOC protected	HCID 17750455	—
Product	(2S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester	HCID 42643336	—

Reaction Steps

11.1 Using general procedure D N-Boc-trans-4-amino-L-proline methyl ester hydrochloride was coupled with 5-chlorothiophene-2-carboxylic acid to give (2S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester. White solid. MS 389.4 ([M+H]+)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07820699B2
Source dataset	uspto-grants-2010_10
ORD ID	ord-c3cf40ceb80b4c0eadb283842b932072
Source note	uspto-grants-2010_10