Hydrochloric Acid → HCID 86608829, compound

Participants

Reaction Steps

17.4 To a stirred solution of 134 mg (2S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carboxylic acid tert-butyl ester at r.t. in 3.4 ml dioxane under an argon atmosphere were added 1.6 ml 4 M HCl in dioxane. The mixture was then stirred for 18 h. The resulting white suspension was concentrated to leave 139 mg 5-chloro-thiophene-2-carboxylic acid ((3R,5S)-5-pyrrolidin-1-ylmethyl-pyrrolidin-3-yl)-amide dihydrochloride as off-white solid. MS 314.3 ([M+H]+)

Provenance & Evidence