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HRID1162636

反应详情

EQUATION

反应方程式

HRID 1162636 的结构方程式

REACTANTS

反应物

2
结构：Nc1ccc(N2CCOCC2=O)cc1F
HCID53417798

4-(4-Amino-3-fluorophenyl)morpholin-3-one

C10H11FN2O2

结构：CCOC(=O)CN1C[C@H](NC(=O)c2ccc(Cl)s2)[C@@H](OC)C1
HCID58748327

未命名化合物

PRODUCTS

生成物

1
结构：CO[C@H]1CN(CC(=O)Nc2ccc(N3CCOCC3=O)cc2F)C[C@@H]1NC(=O)c1ccc(Cl)s1
HCID11979009

未命名化合物

PROCEDURE

实验过程

Using general procedure F {(3S,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-methoxy-pyrrolidin-1-yl}-acetic acid ethyl ester (example 25.2) was reacted with 4-(4-amino-3-fluoro-phenyl)-morpholin-3-one (CAS 438056-69-0) to give 5-chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(3-oxo-morpholin-4-yl)-phenylcar-bamoyl]-methyl}-4-methoxy-pyrrolidin-3-yl)-amide. Yellow solid. MS 511.3 ([M+H]+)