4-(4-Aminophenyl)morpholin-3-one → 5-chloro-thiophene-2-carboxylic acid ((3S,4S)-4-methoxy-1-{[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-methyl}-pyrrolidin-3-yl)-amide

Participants

Reaction Steps

Using general procedure F {(3S,4S)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-methoxy-pyrrolidin-1-yl}-acetic acid ethyl ester (example 25.2) was reacted with 4-(4-aminophenyl)-morpholin-3-one (CAS 438056-69-0) to give 5-chloro-thiophene-2-carboxylic acid ((3S,4S)-4-methoxy-1-{[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-methyl}-pyrrolidin-3-yl)-amide. Yellow solid. MS 493.0 ([M+H]+)

Provenance & Evidence