1-(4-Amino-3-fluorophenyl)pyridin-2-one → HCID 58748249, compound

Participants

Reaction Steps

39.4 Using general procedure F {(R)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-methylene-pyrrolidin-1-yl}-acetic acid ethyl ester was reacted with 1-(4-amino-3-fluoro-phenyl)-1H-pyridin-2-one (CAS 536747-52-1, prepared according to WO 2003045912) to give 5-chloro-thiophene-2-carboxylic acid ((R)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-methylene-pyrrolidin-3-yl)-amide. Yellow solid. MS 487.2 ([M+H]+)

Provenance & Evidence