Lithium hydroxide, monohydrate → HCID 86608832, compound

Participants

Reaction Conditions

Reaction Steps

(3S,4R)-4-[(5-Chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-pyrrolidine-3-carboxylic acid ethyl ester (example 40.4; 0.11 g) is dissolved in THF/water (1:1; 3 ml) and LiOH hydrate (9 mg) is added to the suspension. The mixture is stirred for 2 h at 25° C. The solvent is evaporated to dryness to obtain 0.102 g (95%) lithium (3S,4R)-4-[(5-chloro-thiophene-2-carbonyl)-amino]-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-pyrrolidine-3-carboxylate. White solid. MS 519.3 [M+H+].

Provenance & Evidence