tert-Butyl (3R)-3-(aminomethyl)pyrrolidine-1-carboxylate → (R)-3-{[(5-bromo-4-methyl-thiophene-2-carbonyl)-amino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester

Participants

Reaction Steps

57.1 Using general procedure E, (R)-3-aminomethyl-1-N-tert-butoxycarbonyl-pyrrolidine was coupled with 5-bromo-4-methyl-thiophene-2-carboxylic acid (prepared according to M. Nemec et al., Collection of Czechoslovak Chemical Communications, 1974, 39, 3527) to give (R)-3-{[(5-bromo-4-methyl-thiophene-2-carbonyl)-amino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester. White solid. MS 403.3 ([M−H]−)

Provenance & Evidence