HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl (3R)-3-(aminomethyl)pyrrolidine-1-carboxylate → HCID 58748193, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl (3R)-3-(aminomethyl)pyrrolidine-1-carboxylate | HCID 1515152 | — |
| Reactant | 2-Chloro-1,3-thiazole-4-carboxylic acid | HCID 21803026 | — |
| Product | HCID 58748193 | HCID 58748193 | — |
Reaction Steps
61.1 Using general procedure E, (R)-3-aminomethyl-1-N-tert-butoxycarbonyl-pyrrolidine was coupled with 2-chloro-thiazole-4-carboxylic acid (prepared according to R. Walsh et al. Chimica Therapeutica, 1973, 8, 199) to give (R)-3-{[(2-chloro-thiazole-4-carbonyl)-amino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester. White solid. MS 343.9 ([M−H]−)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07820699B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-db1b1c7f82194acdadf34cbb837ee3f9 |
| Source note | uspto-grants-2010_10 |