4-Methoxybenzoic Acid → HCID 58748229, compound

HRID 1162672Notes

Reaction equation

HRID 1162672 reaction equation
[NH2:1][CH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4]1.[CH3:15][O:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](O)=[O:22])=[CH:19][CH:18]=1>>[C:11]([O:10][C:8]([N:5]1[CH2:6][CH2:7][C@H:3]([CH2:2][NH:1][C:21](=[O:22])[C:20]2[CH:24]=[CH:25][C:17]([O:16][CH3:15])=[CH:18][CH:19]=2)[CH2:4]1)=[O:9])([CH3:14])([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 74784-Methoxybenzoic AcidHCID 1515152tert-Butyl (3R)-3-(aminomethyl)pyrrolidine-1-carboxylate

Product 1

HCID 58748229HCID 58748229, compound

Procedure

64.1 Using general procedure E, (R)-3-aminomethyl-1-N-tert-butoxycarbonyl-pyrrolidine was coupled with 4-methoxy-benzoic acid to give (R)-3-[(4-methoxy-benzoylamino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester. Yellow oil. MS 335.1 ([M+H]+)

Sources & evidence

ORD record
ord-ab711aaf120c41d9a00c561e1aac5267
Source dataset
uspto-grants-2010_10
Patent number
US07820699B2

Reaction notes

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