5-Chloro-1-benzothiophene-2-carboxylic acid → HCID 58748238, compound

HRID 1162675Notes

Reaction equation

HRID 1162675 reaction equation
[NH2:1][CH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4]1.[Cl:15][C:16]1[CH:27]=[CH:26][C:19]2[S:20][C:21]([C:23](O)=[O:24])=[CH:22][C:18]=2[CH:17]=1>>[C:11]([O:10][C:8]([N:5]1[CH2:6][CH2:7][C@H:3]([CH2:2][NH:1][C:23]([C:21]2[S:20][C:19]3[CH:26]=[CH:27][C:16]([Cl:15])=[CH:17][C:18]=3[CH:22]=2)=[O:24])[CH2:4]1)=[O:9])([CH3:14])([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 9014385-Chloro-1-benzothiophene-2-carboxylic acidHCID 1515152tert-Butyl (3R)-3-(aminomethyl)pyrrolidine-1-carboxylate

Product 1

HCID 58748238HCID 58748238, compound

Procedure

66.1 Using general procedure E, (R)-3-aminomethyl-1-N-tert-butoxycarbonyl-pyrrolidine was coupled with 5-chloro-benzo[b]thiophene-2-carboxylic acid to give (R)-3-{[(5-chloro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester. White solid. MS 392.9 ([M−H]−)

Sources & evidence

ORD record
ord-dbe353f36f404a28aab34fa5512f591f
Source dataset
uspto-grants-2010_10
Patent number
US07820699B2

Reaction notes

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