HCID 18453166, compound → HCID 58748211, compound

HRID 1162693Notes

Reaction equation

HRID 1162693 reaction equation
FC(F)(F)C(O)=O.[NH:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[CH2:13][NH:14][C:15]([C:17]1[S:18][C:19]([Cl:22])=[CH:20][CH:21]=1)=[O:16].[F:23][C:24]1[CH:32]=[C:31]([N:33]2[CH:38]=[CH:37][CH:36]=[CH:35][C:34]2=[O:39])[CH:30]=[CH:29][C:25]=1[C:26](O)=[O:27]>>[F:23][C:24]1[CH:32]=[C:31]([N:33]2[CH:38]=[CH:37][CH:36]=[CH:35][C:34]2=[O:39])[CH:30]=[CH:29][C:25]=1[C:26]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[CH2:13][NH:14][C:15]([C:17]1[S:18][C:19]([Cl:22])=[CH:20][CH:21]=1)=[O:16])=[O:27]

Participants

3

Reactant 2

HCID 18453166HCID 18453166, compoundHCID 131728407HCID 131728407, compound

Product 1

HCID 58748211HCID 58748211, compound

Procedure

Using general method H, rac-5-chloro-thiophene-2-carboxylic acid (pyrrolidin-2-ylmethyl)-amide trifluoro acetate (example 75.2) was reacted with 2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-benzoic acid (prepared according to example 54.1) to give rac-5-chloro-thiophene-2-carboxylic acid {1-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-benzoyl]-pyrrolidin-2-ylmethyl}-amide. White solid. MS 460.0 ([M+H]+)

Sources & evidence

ORD record
ord-54567a12b6a04281a06c42d61e919399
Source dataset
uspto-grants-2010_10
Patent number
US07820699B2

Reaction notes

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