Carbamic acid, [[(3R,4R)-4-(trifluoromethyl)-3-pyrrolidinyl]methyl]-, 1,1-dimethylethyl ester, rel- → HCID 58748306, compound

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Reaction Steps

77.1 Using general procedure H, (3S,4S)-(4-trifluoromethyl-pyrrolidin-3-ylmethyl)-carbamic acid tert-butyl ester (H. Fukui et al., Bioorganic & Medicinal Chemistry Letters, 1998, 8, 2833) was coupled with [2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-carbamic acid 4-nitro-phenyl ester (prepared according to example 54.3) to give {(3R,4S)-1-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-4-trifluoromethyl-pyrrolidin-3-ylmethyl}-carbamic acid tert-butyl ester. Orange oil. MS 499.3 ([M+H]+)

Provenance & Evidence