反应详情

79.3 A suspension of (3S,4S)-3-acetoxy-4-cyano-pyrrolidine-1-carboxylic acid tert-butyl ester (89 mg) in 10 ml of AcOEt and 0.2 ml of chloroform, 0.2 ml of AcOH and 4 mg of PtO2 was hydrogenated at 22° C. and atmospheric pressure for 16 h. The suspension was filtered and the filtrate evaporated to give (3S,4R)-3-acetoxy-4-aminomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester acetate. Colorless semisolid. MS 259.3 ([M+H]+)

1. customwas hydrogenated at 22° C.
2. filtrationThe suspension was filtered
3. customthe filtrate evaporated