反应详情

79.5 A solution of (3S,4R)-3-acetoxy-4-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester (20 mg) in 1 ml of a 2M NH3 solution in MeOH was stirred at 22° C. for 1 h and evaporated to give (3R,4S)-3-{[(5-chloro-thiophene-2-carbonyl)-amino]-methyl}-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester. Pale brown oil. MS 305.1 ([M-isobutene+H]+)

1. customevaporated