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HRID1162701

反应详情

EQUATION

反应方程式

HRID 1162701 的结构方程式

REACTANTS

反应物

2
结构：N
HCID222

Ammonia gas

H3N

结构：CC(=O)O[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1C#N
HCID68647086

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1C[C@@H](O)[C@H](C#N)C1
HCID58748337

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

80.1 A solution of (3S,4S)-3-acetoxy-4-cyano-pyrrolidine-1-carboxylic acid tert-butyl ester (1.00 g, prepared according to example 79.2) in 10 ml of a 2M NH3 solution in MeOH was stirred at 22° C. for 1 h and evaporated. The residue was chromatographed on silica (heptane/AcOEt, 2.5:1) to give (3S,4S)-3-cyano-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester. Colorless solid. MS 213.3 ([M+H]+)

WORKUP

后处理

  1. customevaporated
  2. customThe residue was chromatographed on silica (heptane/AcOEt, 2.5:1)